The most common and most likely answer to this crossword clue is the 9 letter word NUCLEATOR
I've seen this crossword clue in The Guardian
N
U
C
L
E
A
T
O
R
Buddy explains!
The straight part
We know that "What makes middle of cell" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what makes middle of cell = nucleator.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.