Cryptic crossword clue
What makes you blue and sorrow’d, say? 4

The most common and most likely answer to this crossword clue is the 4 letter word WOAD

I've seen this crossword clue in The Guardian
W
O
A
D

Buddy explains!

The straight part
We know that "What makes you blue" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what makes you blue = woad.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WOAD mean?

WOAD noun
  1. The plant Isatis tinctoria.
  2. The blue dye made from the leaves of the plant.
WOAD verb
  1. To plant or cultivate woad.
  2. To dye with woad.

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