Cryptic crossword clue
What might be certain to describe answer: having a skull

The most common and most likely answer to this crossword clue is the 8 letter word CRANIATE

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "having a skull" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case having a skull = craniate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CRANIATE mean?

CRANIATE noun
  1. Any member of the clade Craniata, having bony skulls.

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