The most common and most likely answer to this crossword clue is the 3 plus 4 plus 2 plus 6 letter word YOU WILL BE MISSED
Y
O
U
W
I
L
L
B
E
M
I
S
S
E
D
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.