Cryptic crossword clue
What to call a mistress one madly screwed over 6

The most common and most likely answer to this crossword clue is the 6 letter word MILADY

M
I
L
A
D
Y

Buddy explains!

The straight part
We know that "what to call a mistress" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what to call a mistress = milady.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MILADY mean?

MILADY noun
  1. An English noblewoman or gentlewoman; the form of address to such a person; a lady.

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