The most common and most likely answer to this crossword clue is the 3 plus 7 letter word GET KNOTTED
I've seen this crossword clue in Financial Times
G
E
T
K
N
O
T
T
E
D
More clues leading to the result GET KNOTTED
Buddy explains!
The straight part
We know that "What your muscles may do/on your bike" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what your muscles may do/on your bike = get knotted.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.