Cryptic crossword clue
What’s applied during period in ER 6

The most common and most likely answer to this crossword clue is the 6 letter word IODINE

I've seen this crossword clue in The Guardian
I
O
D
I
N
E

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The straight part
We know that "What’s applied during period in ER" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what’s applied during period in er = iodine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IODINE mean?

IODINE noun
  1. A chemical element (symbol: I) with an atomic number of 53; one of the halogens.
  2. An antiseptic incorporating the element.
  3. An iodide.
IODINE verb
  1. To treat with iodine.

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