The most common and most likely answer to this crossword clue is the 4 letter word CAUP
C
A
U
P
Buddy explains!
The straight part
We know that "What’s better wi’ wee bit of usquebaugh in it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what’s better wi’ wee bit of usquebaugh in it = caup.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.