The most common and most likely answer to this crossword clue is the 6 plus 6 letter word -O---E GOITRE
-
O
-
-
-
E
G
O
I
T
R
E
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.