The most common and most likely answer to this crossword clue is the 8 plus 4 letter word IMMORTAL SOUL
I
M
M
O
R
T
A
L
S
O
U
L
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.