Cryptic crossword clue
When at sea I travel North-East and run off the point

The most common and most likely answer to this crossword clue is the 10 letter word IRRELEVANT

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "off the point" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case off the point = irrelevant.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IRRELEVANT mean?

IRRELEVANT adjective
  1. Not related, not applicable, unimportant, not connected.

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