The most common and most likely answer to this crossword clue is the 8 letter word CORONARY
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does CORONARY mean?
CORONARY noun- Any of the coronary vessels; a coronary artery or coronary vein.
- A small bone in the foot of a horse.
- Pertaining to a crown or garland.
- Encircling something (like a crown), especially with regard to the arteries or veins of the heart.
- Thrombosis of a coronary artery, that is, a blockage, caused by a blood clot, of the blood flow in a coronary artery of the heart, leading to myocardial infarction.