Cryptic crossword clue
Where one might go with degree, given a difficult time

The most common and most likely answer to this crossword clue is the 10 letter word INCOMMODED

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "given a difficult time" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case given a difficult time = incommoded.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INCOMMODED mean?

INCOMMODED verb
  1. To disturb, to discomfort, to hinder.

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