Cryptic crossword clue
Why, say, a setter here is disturbed about a Spanish uncle — it’s enough to take one’s breath away 12

The most common and most likely answer to this crossword clue is the 12 letter word ASPHYXIATION

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "it’s enough to take one’s breath away" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it’s enough to take one’s breath away = asphyxiation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASPHYXIATION mean?

ASPHYXIATION noun
  1. Death due to lack of oxygen.
  2. An acute lack of oxygen.

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