Cryptic crossword clue
Wipe out Athenian rebels, saving the Italian 10

The most common and most likely answer to this crossword clue is the 10 letter word ANNIHILATE

I've seen this crossword clue in Financial Times
A
N
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I
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Buddy explains!

The straight part
We know that "Wipe ou" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case wipe ou = annihilate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANNIHILATE mean?

ANNIHILATE verb
  1. To reduce to nothing, to destroy, to eradicate.
  2. To react with antimatter, producing gamma radiation.
  3. To treat as worthless, to vilify.
  4. To render null and void; to abrogate.

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