Cryptic crossword clue
Wise guy hurt, plonker initially poking nasty wound 11

The most common and most likely answer to this crossword clue is the 11 letter word SMARTYPANTS

I've seen this crossword clue in The Sunday Telegraph
S
M
A
R
T
Y
P
A
N
T
S

Buddy explains!

The straight part
We know that "Wise guy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case wise guy = smartypants.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SMARTYPANTS mean?

SMARTYPANTS noun
  1. A smart aleck or know-it-all.

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