The most common and most likely answer to this crossword clue is the 6 letter word NATURE
I've seen this crossword clue in The Times
N
A
T
U
R
E
More clues leading to the result NATURE
- Wise, having name for male disposition
- Unspoilt scenery Nathaniel found by northern river
- Wildlife, etc, at old city in north-east
- Character of science magazine
- Sort seen in china tureen
- Kind disposition
- Character breaking tea urn
- Character that may be associated with reserve?
- Character’s name for maiden in bloom?
- Condition in SNP member for one with Scottish musician
Buddy explains!

The straight part
We know that "disposition" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disposition = nature.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does NATURE mean?
NATURE noun- The natural world; that which consists of all things unaffected by or predating human technology, production, and design. (Compare ecosystem.)
- The innate characteristics of a thing. What something will tend by its own constitution, to be or do. Distinct from what might be expected or intended.
- The summary of everything that has to do with biological, chemical and physical states and events in the physical universe.
- Conformity to that which is natural, as distinguished from that which is artificial, or forced, or remote from actual experience.
- Kind, sort; character; quality.
- Physical constitution or existence; the vital powers; the natural life.
- Natural affection or reverence.
- To endow with natural qualities.