The most common and most likely answer to this crossword clue is the 5 letter word DIRAC
I've seen this crossword clue in The Times
D
I
R
A
C
More clues leading to the result DIRAC
- Wit from the south captivates one Nobel laureate
- Physicist emerging from motorcar I drove northward
- Nobel laureate is debtor without current account
- Physicist brought back free air- conditioning
- Head of Institute blocks return of eccentric English physicist
- Scientist returned vehicle to policeman
- Physicist sporting cardi
- Physicist, reverse of barren, given constant
- Physicist I introduced to rising wit
- Eccentric character turning up to entertain one, a famous physicist
Buddy explains!

The straight part
We know that "Nobel laureate" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nobel laureate = dirac.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.