The most common and most likely answer to this crossword clue is the 6 letter word SPILED
S
P
I
L
E
D
Buddy explains!
The straight part
We know that "With a stake in" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with a stake in = spiled.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SPILED mean?
SPILED verb- To plug (a hole) with a spile.
- To draw off (a liquid) using a spile.
- To provide (a barrel, tree etc.) with a spile.
- To support by means of spiles.
- To drive piles into.
- Spoil.