The most common and most likely answer to this crossword clue is the 2 plus 3 plus 5 letter word TO THE DEATH
I've seen this crossword clue in The Times
T
O
T
H
E
D
E
A
T
H
Buddy explains!
The straight part
We know that "without ever letting up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case without ever letting up = to the death.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.