The most common and most likely answer to this crossword clue is the 3 plus 2 plus 4 letter word ILL AT EASE
I've seen this crossword clue in The Times
I
L
L
A
T
E
A
S
E
More clues leading to the result ILL AT EASE
- With misgivings, I seal newly dead within
- A kid on medication, powerless and uncomfortable
- Uncomfortable with allies failing to eat meal
- I'm going to answer guy that's awkward
- Sick with a kid that’s fidgety, perhaps
- Concealing face, house flirt uncomfortable
- Jack’s partner going topless, a provocation making you embarrassed
- Relax after I exaggerated about being anxious
- Will ate a second helping which made him uncomfortable
- Anxious setter will tantalise, concealing answer
Buddy explains!
The straight part
We know that "With misgivings" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with misgivings = ill at ease.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.