Cryptic crossword clue
With no hesitation saintly and not heartless in trouble 9

The most common and most likely answer to this crossword clue is the 9 letter word INSTANTLY

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Buddy explains!

The straight part
We know that "With no hesitation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with no hesitation = instantly.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INSTANTLY mean?

INSTANTLY adverb
  1. At once; without delay.
  2. Urgently; with insistence.
  3. At the same time.

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