Cryptic crossword clue
With no humility, half of mum’s brothers advanced 11

The most common and most likely answer to this crossword clue is the 11 letter word UNCHASTENED

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Buddy explains!

The straight part
We know that "With no humility" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with no humility = unchastened.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNCHASTENED mean?

UNCHASTENED adjective
  1. Not chastened or rebuked.

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