Cryptic crossword clue
With no will to cross Republican: that’s the US way 10

The most common and most likely answer to this crossword clue is the 10 letter word INTERSTATE

I've seen this crossword clue in The Times
I
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Buddy explains!

The straight part
We know that "the US way" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the us way = interstate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTERSTATE mean?

INTERSTATE noun
  1. A freeway that is part of the Interstate Highway System.
INTERSTATE adjective
  1. Of, or relating to two or more states.
INTERSTATE adverb
  1. Crossing states (usually provincial state, but also e.g. multinational sense).

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