The most common and most likely answer to this crossword clue is the 10 letter word DIVINATION
I've seen this crossword clue in The Guardian
D
I
V
I
N
A
T
I
O
N
More clues leading to the result DIVINATION
Buddy explains!
The straight part
We know that "prediction" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case prediction = divination.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DIVINATION mean?
DIVINATION noun- The act of divining; a foreseeing or foretelling of future events.
- The apparent art of discovering secrets or the future by preternatural means.
- An indication of what is to come in the future or what is secret; a prediction.