Cryptic crossword clue
With reference to Heartbeat, shooting is costly 8

The most common and most likely answer to this crossword clue is the 8 letter word SYSTOLIC

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Buddy explains!

The straight part
We know that "With reference to Heartbeat" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with reference to heartbeat = systolic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SYSTOLIC mean?

SYSTOLIC noun
  1. Short for systolic blood pressure.
SYSTOLIC adjective
  1. Pertaining to a systole or heart contraction
  2. Relating to a systolic array
  3. Simply connected and having multiple diagonals

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