The most common and most likely answer to this crossword clue is the 5 letter word ICILY
I
C
I
L
Y
More clues leading to the result ICILY
- Top Mediterranean island showing hostility
- Son’s removed from European island in a chilling way
- Nursing cold, one doubled up lay disheartened, with very little warmth
- With reserve in Mafia country when son’s missing
- Mediterranean island's leader moving away in an aloof manner
- Italian island ousting its leader without much warmth
- Mediterranean island without its leader is in a hostile state
Buddy explains!

The straight part
We know that "With reserve" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with reserve = icily.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.