Cryptic crossword clue
Without giving up could give sister plenty 12

The most common and most likely answer to this crossword clue is the 12 letter word PERSISTENTLY

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Buddy explains!

The straight part
We know that "Without giving up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case without giving up = persistently.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PERSISTENTLY mean?

PERSISTENTLY adverb
  1. In a persistent manner.

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