The most common and most likely answer to this crossword clue is the 8 letter word SHRUNKEN
I've seen this crossword clue in The Times
S
H
R
U
N
K
E
N
Buddy explains!
The straight part
We know that "Wizened" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case wizened = shrunken.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SHRUNKEN mean?
SHRUNKEN verb- To cause to become smaller.
- To become smaller; to contract.
- To cower or flinch.
- To draw back; to withdraw.
- To withdraw or retire, as from danger.
- To move back or away, especially because of fear or disgust.
- Reduced in size as a result of shrinkage; shrivelled.