Cryptic crossword clue
Woman boss to question Tim’s being involved with lock-out 12

The most common and most likely answer to this crossword clue is the 12 letter word TASKMISTRESS

T
A
S
K
M
I
S
T
R
E
S
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TASKMISTRESS mean?

TASKMISTRESS noun
  1. A woman who assigns tasks; a female overseer.

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