Cryptic crossword clue
Woman’s obsession for the other JFK, here? Politician: “Hard replacing leader of country” 11

The most common and most likely answer to this crossword clue is the 11 letter word NYMPHOMANIA

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Woman’s obsession for the other" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case woman’s obsession for the other = nymphomania.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NYMPHOMANIA mean?

NYMPHOMANIA noun
  1. Excess of sexual behaviour or desire in women.

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