The most common and most likely answer to this crossword clue is the 5 plus 5 letter word ALTAR PIECE
A
L
T
A
R
P
I
E
C
E
Buddy explains!
The straight part
We know that "Work of art at church" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case work of art at church = altar piece.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.