The most common and most likely answer to this crossword clue is the 4 plus 2 letter word TUNE UP
I've seen this crossword clue in The Daily Telegraph
T
U
N
E
U
P
More clues leading to the result TUNE UP
Buddy explains!
The straight part
We know that "Work on engine" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case work on engine = tune up.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TUNE UP mean?
TUNE UP noun- A series of adjustments to an engine in order to improve its performance
- A series of preparations for vigorous exercise; a warm-up
- A match or race (frequently one exhibition in nature) contested as preparation for a match or race of high stakes.