The most common and most likely answer to this crossword clue is the 10 letter word EMPLOYMENT
I've seen this crossword clue in Independent
E
M
P
L
O
Y
M
E
N
T
More clues leading to the result EMPLOYMENT
Buddy explains!

The straight part
We know that "Work" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case work = employment.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EMPLOYMENT mean?
EMPLOYMENT noun- The work or occupation for which one is used, and often paid
- The act of employing
- A use, purpose
- The state of being employed
- An activity to which one devotes time
- The number or percentage of people at work