The most common and most likely answer to this crossword clue is the 5 letter word AGONY
A
G
O
N
Y
More clues leading to the result AGONY
- Suffering some to be blocked by progress
- Suffering such aunts and uncles?
- American city encapsulating success and suffering
- Torment some bridge game
- Anguish in New York following a turn
- Suffering in the past ends in plain misery
- Indefinite number engaged in system of exercises standing on head in pain
- Try to block some pain
- Work through some excruciating pain
- Any attempt to inject is painful
Buddy explains!

The straight part
We know that "excruciating pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case excruciating pain = agony.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AGONY mean?
AGONY noun- Extreme pain.
- The sufferings of Jesus Christ in the garden of Gethsemane.
- Violent contest or striving.
- Paroxysm of joy; keen emotion.
- The last struggle of life; death struggle.