The most common and most likely answer to this crossword clue is the 12 letter word DOUBLE-CLICK
I've seen this crossword clue in The Guardian
D
O
U
B
L
E
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C
L
I
C
K
Buddy explains!
The straight part
We know that "Work with mouse" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case work with mouse = double-click.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DOUBLE-CLICK mean?
DOUBLE-CLICK noun- The action of pushing the button on a mouse twice in quick succession in order to perform a different task that would be performed from a single-click or triple-click.
- To push the button on a mouse twice in quick succession in order to perform a different task than would be performed from a single-click or triple-click.