Cryptic crossword clue
Working with numbers, put in ten, as an eight is wrong 14

The most common and most likely answer to this crossword clue is the 14 letter word ANAESTHETISING

I've seen this crossword clue in The Sunday Telegraph
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Buddy explains!

The straight part
We know that "Working with numbers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case working with numbers = anaesthetising.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANAESTHETISING mean?

ANAESTHETISING verb
  1. To administer anesthesia to: to render unfeeling or unconscious through the use of narcotic substances, usually either alcohol or pharmaceutical drugs.

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