Cryptic crossword clue
Worry constantly occupying outlaw anguished in retreat 4

The most common and most likely answer to this crossword clue is the 4 letter word GNAW

G
N
A
W

Buddy explains!

The straight part
We know that "Worry constantly" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case worry constantly = gnaw.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GNAW mean?

GNAW verb
  1. To bite something persistently, especially something tough.
  2. To produce excessive anxiety or worry.
  3. To corrode; to fret away; to waste.

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