Cryptic crossword clue
Worthless items shut up, and shut up again! 6

The most common and most likely answer to this crossword clue is the 6 letter word SHLOCK

S
H
L
O
C
K

Buddy explains!

The straight part
We know that "Worthless items" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case worthless items = shlock.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SHLOCK mean?

SHLOCK noun
  1. Commodity that is shoddy or inferior.

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