The most common and most likely answer to this crossword clue is the 8 letter word DENATURE
I've seen this crossword clue in The Times
D
E
N
A
T
U
R
E
Buddy explains!
The straight part
We know that "Wreck" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case wreck = denature.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DENATURE mean?
DENATURE verb- To take away a natural characteristic or inherent property of (a thing or a person).
- To add something to (alcohol) that makes it unsuitable for consumption but leaves it suitable for other purposes.
- To alter its original form or state, especially of a protein, by heat, acidity etc.
- To combine fissionable material with nonfissionable material in order to prevent its use in an atomic weapon.