Cryptic crossword clue
Wrinkles up, vanity half gone? It’s a hazard of old age 8

The most common and most likely answer to this crossword clue is the 8 letter word SENILITY

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "a hazard of old age/a hazard of old age" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a hazard of old age/a hazard of old age = senility.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SENILITY mean?

SENILITY noun
  1. Senescence; the bodily and mental deterioration associated with old age.
  2. The losing of memory and reason due to senescence.
  3. An elderly, senile person.

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