The most common and most likely answer to this crossword clue is the 13 letter word TRANQUILLISER
I've seen this crossword clue in The Times
T
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A
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Q
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More clues leading to the result TRANQUILLISER
Buddy explains!

The straight part
We know that "pill" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pill = tranquilliser.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TRANQUILLISER mean?
TRANQUILLISER noun- That which tranquillizes or soothes.
- A drug used to reduce anxiety or tension; a sedative.