The most common and most likely answer to this crossword clue is the 12 letter word INDEPENDENCE
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More clues leading to the result INDEPENDENCE
- Elected Democrat: “Need Pence to break up liberty”
- Nine needed PC corrupted to get freedom
- Freedom to swim in deep end, hence he sunk
- In freedom recollected nice deed associated with Penn
- Dine out with coppers, restricting study for freedom
- Fresh new epic needed about national freedom
- Ended nice meandering about writer’s freedom
- Standing alone in deep end moving a bit, pleasant but I must get out
- Dine out and tip in change showing autonomy
- Liberty‘s desire for some Scotch?
Buddy explains!

The straight part
We know that "autonomy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case autonomy = independence.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INDEPENDENCE mean?
INDEPENDENCE noun- The state or quality of being independent; freedom from dependence; exemption from reliance on, or control by others; self-subsistence or maintenance; direction of one's own affairs without interference.
- The state of having sufficient means for a comfortable livelihood.