Cryptic crossword clue
Writer of Spanish origin, involved in latest study on church's autonomy 12

The most common and most likely answer to this crossword clue is the 12 letter word INDEPENDENCE

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Buddy explains!

The straight part
We know that "autonomy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case autonomy = independence.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INDEPENDENCE mean?

INDEPENDENCE noun
  1. The state or quality of being independent; freedom from dependence; exemption from reliance on, or control by others; self-subsistence or maintenance; direction of one's own affairs without interference.
  2. The state of having sufficient means for a comfortable livelihood.

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