Cryptic crossword clue
Writhing in agony, holding front of nose, becoming tiresome 8

The most common and most likely answer to this crossword clue is the 8 letter word ANNOYING

I've seen this crossword clue in The Sunday Telegraph
A
N
N
O
Y
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G


Buddy explains!

The straight part
We know that "tiresome" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tiresome = annoying.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANNOYING mean?

ANNOYING verb
  1. To disturb or irritate, especially by continued or repeated acts; to bother with unpleasant deeds.
  2. To do something to upset or anger someone; to be troublesome.
  3. To molest; to harm; to injure.
ANNOYING noun
  1. That which annoys; an annoyance.
ANNOYING adjective
  1. Causing irritation or annoyance; troublesome; vexatious.

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