Cryptic crossword clue
Wrong dose ain’t calming someone down 8

The most common and most likely answer to this crossword clue is the 8 letter word SEDATION

I've seen this crossword clue in The Sunday Telegraph
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Buddy explains!

The straight part
We know that "calming someone down" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case calming someone down = sedation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEDATION mean?

SEDATION noun
  1. The act of sedating, especially by use of sedatives.

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