Cryptic crossword clue
Wrong subtractions standing in the way of enlightenment 12

The most common and most likely answer to this crossword clue is the 12 letter word OBSCURANTIST

I've seen this crossword clue in The Sunday Telegraph
O
B
S
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U
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A
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Buddy explains!

The straight part
We know that "standing in the way of enlightenment" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case standing in the way of enlightenment = obscurantist.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

OBSCURANTIST noun
  1. A practitioner of obscurantism; an obscurant

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