The most common and most likely answer to this crossword clue is the 6 letter word ESTHER
E
S
T
H
E
R
More clues leading to the result ESTHER
- Girl seen in vest here
- Job to follow this wild-west hero’s part
- Son visiting heaven once in religious book
- Book three’s complicated
- Book advises the right clothes
- Part of Bible’s there?
- Woman housed originally in compound
- In east of France, a woman’s book
- Woman among bravest heroines
- Book showing hydrogen in organic compound
Buddy explains!

The straight part
We know that "Xerxes’ wife" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case xerxes’ wife = esther.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.