Cryptic crossword clue
Yankee Doodle heartlessly played with absence of instruments 5,3

The most common and most likely answer to this crossword clue is the 5 plus 3 letter word NAKED EYE

N
A
K
E
D
E
Y
E


Buddy explains!

The straight part
We know that "with absence of instruments" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with absence of instruments = naked eye.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NAKED EYE mean?

NAKED EYE adjective
  1. Pertaining to the unaided eye, as in unaided sight.

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