Cryptic crossword clue
You and I reflected after moderate disease 6

The most common and most likely answer to this crossword clue is the 6 letter word MILDEW

M
I
L
D
E
W


Buddy explains!

The straight part
We know that "disease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disease = mildew.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MILDEW mean?

MILDEW noun
  1. A growth of minute powdery or webby fungi, whitish or of different colors, found on various diseased or decaying substances.
MILDEW verb
  1. To taint with mildew.
  2. To become tainted with mildew.

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