Cryptic crossword clue
Youngsters spotted with it cross Yellow River first 10

The most common and most likely answer to this crossword clue is the 10 letter word CHICKENPOX

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "Youngsters spotted with it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case youngsters spotted with it = chickenpox.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHICKENPOX mean?

CHICKENPOX noun
  1. A common childhood disease caused by the varicella zoster virus (VZV), Human alphaherpesvirus 3 (HHV-3).

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